A Positive Antidote

A PoTENtial Antidote

The direct oral anticoagulants (DOACs), which include dabigatran, rivaroxaban, apixaban, and edoxaban, can be given in fixed doses without routine coagulation monitoring. In clinical trials, the DOACs have been shown to be at least as effective as vitamin K antagonists (VKAs), such as warfarin, for stroke prevention in nonvalvular atrial fibrillation and for treatment of venous thromboembolism,...

Translational Antidote Research: A Bedside to Bench Tale

Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...

The Metamorphosis Antidote

Previews by catalyzing the removal of iodine from the inner ring. When the function of D3 was inactivated by iopanoic acid (IOPA), a specific inhibitor of the enzyme, the asym-metric growth pattern in response to thyroid hormone What if you woke up one morning and your eyes were was lost, and both dorsal and ventral CMZ grew equally. on the top of your head? You would be confused to see In comp...

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Physostigmine as an Antidote

Introduction: Rapid treatment of patients with anticholinergic toxicity in the Ernergcncy Department (ED) has remained problematic for many years. These patients are often agitated. uncooperative, and unable to provide a clear history. Physostigmine is a specific antidote for anticholinergic toxicity. yet its popularity has waned due to controversy surrounding its potential central nervo~is sys...